Academia Sinica-Cryo-EM Structure of the Vaccinia Virus Entry Fusion Complex Reveals a Multicomponent Fusion Machinery. Lin CSH, Li CA, Wang CH, Kao CF, Chiu HJ, Yeh MC, Gao HD, Ho MC, Lee HM, Chang W.  Membrane fusion is essential for viral entry. Unlike class I–III fusion proteins, vaccinia virus employs a multi-component Entry Fusion Complex (EFC). Using cryo–electron microscopy, we determined the full-length structure of the vaccinia EFC... Read more

Cryo-EM structure of the vaccinia virus entry fusion complex reveals a multicomponent fusion machinery.

Lin CSH, Li CA, Wang CH, Kao CF, Chiu HJ, Yeh MC, Gao HD, Ho MC, Lee HM, Chang W. Science Advances (2026)

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Dendritic cell-targeted liposomes for cancer immunotherapy via inhibition of aryl hydrocarbon receptor.

Zhang CG, Yeh CY, Hsu SY, Prakash M, Abarientos AB, Chiang-Hsieh HM, Lin YY, Ortiz CLD, Yang LW, Liang PH, Wu HC, Lee YL. Journal of Nanobiotechnology (2025)

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Structural basis of K11/K48-branched ubiquitin chain recognition by the human 26S proteasome.

Draczkowski P, Chen SN, Chen T, Wang YS, Shih HA, Huang JYC, Tsai MC, Lin SY, Lin S, Viner R, Chang YC, Wu KP & Hsu STD. Nature Communications (2025) Video

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