| Research Highlights |
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Visualization of the first contact between the earliest reported human coronavirus and its human receptor molecule |
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Tsai, YX, Chien YC, Hsu MF, Khoo KY, Hsu ST
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Structural Basis and Synergism of ATP and Na+ Activation in Bacterial K+ Uptake System KtrAB |
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Chiang WTien, Chang YK, Hui WH, Chang SW, Liao CY, Chang YC, Chen CJ, Wang WC, Lai CC, Wang CH, Luo SY, Huang YP, Chou SH, Horng TL, Hou MH, Muench SP, Chen RS, Tsai MD*, Hu NJ*
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GlycoSHIELD – quantitative descriptions of the shielding effects and biological implications of protein glycosylation |
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Tsai YX, Chang NE, Reuter K, Chang HT, Yang TJ, von Bülow S, Sehrawat V, Zerrouki M, Tuffery M, Gecht M, Grothaus IL, Ciacchi LC, Wang YS, Hsu MF, Khoo KH, Hummer G, Hsu STD*, Hanus C*, Sikora M*
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A structure of the relict phycobilisome from a thylakoid-free cyanobacterium |
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Jiang HW, Wu HY, Wang CH, Yang CH, Ko JT, Ho HC, Tsai MD, Bryant DA, Li FW, Ho MC*, Ho MY*
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CryoEM Reveals Mechanism Behind Polymyxin-Resistant Infections |
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Lou YC*, Huang HY, Yeh HH, Chiang WH, Chen C*, Wu KP*
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Academia Sinica Team Discovers a New Method to Increase Carbon Fixation for Improving Carbon Balance |
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Lu KJ, Chang CW, Wang CH, Chen FY, Huang IY, Huang PH, Yang CH, Wu HY, Wu WJ, Hsu KC, Ho MC, Tsai MD*, Liao JC*
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Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2 |
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Huang KY*, Chen XR, Mohapatra A, Nguyen HTV, Schimanski L, Tan TK, Rijal P, Vester SK, Hills RA, Howarth M, Keeffe JR, Cohen AA, Kakutani LM, Wu YM, Mahmud Md SA, Chou YC, Bjorkman PJ, Townsend AR, Ma C*
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Cryo-electron tomography reveals the structure and dynamics of an alphacoronavirus spike protein |
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Huang CY, Draczkowski P, Wang YS, Chang CY, Chien YC, Cheng YH, Wu YM, Wang CH, Chang YC, Chang YC, Yang TJ, Tsai YX, Khoo KH, Chang HW, Hsu STD*
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Mono-GlcNAc-decorated spike vaccine is highly effective against COVID-19 variants |
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Huang HY, Liao HY, Chen XR, Wang SW, Cheng CW, Mahmud MSA, Liu YM, Mohapatra A, Chen TH, Lo JM, Wu YM, Ma HH, Chang YH, Tsai HY, Chou YC, Hsueh YP, Tsai CY, Huang PY Chang SY, Chao TL, Kao HC, Tsai YM, Chen YH, Wu CY, Jan JT, Cheng TJR, Lin KI*, Ma C*, Wong CH*
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Therapeutic Antibody Cocktail for Prevention and Treatment of COVID-19 |
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Su SC, Yang TJ, Yu PY, Liang KH, Chen WY, Yang CW, Lin HT, Wang MJ, Lu RM, Tso HC, Chung MJ, Hsieh TY, Chang YL, Lin SC, Hsu FY, Ke FY, Wu YH, Hwang YC, Liu IJ, Liang JJ, Liao CC, Ko HY, Sun CP, Wu PY, Jan JT, Chang YC, Lin YL*, Tao MH*, Hsu STD*, Wu HC*
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Molecular insights into the increased transmissibility and immunity evasion of the SARS-CoV-2 Alpha variant |
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Yang TJ, Yu PY, Chang YC, Liang KH, Tso HC, Ho MR, Chen WY, Lin HT, Wu HC, Hsu STD*
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Copper Centers in the Cryo-EM Structure of Particulate Methane Monooxygenase Reveal the Catalytic Machinery of Methane Oxidation |
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Chang WH*, Lin HH, Tsai IK, Huang SH, Chung SC, Tu IP, Yu SSF*, Chan SI*
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| ● |
Direct Visualization of a 26 kDa Protein by Cryo-Electron Microscopy Aided by a Small Scaffold Protein |
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Chiu YH, Ko KT, Yang TJ, Wu KP, Ho MR, Draczkowski P*, Hsu STD*
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Perfection in the imperfection – molecular mechanism for genetic diversity |
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Luo SC, Yeh HY, Lan WH, Wu YM, Yang CH, Chang HY, Su GC, Lee CY, Wu WJ, Li HW, Ho MC*, Chi P*, Tsai MD*
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FRIL Can Grab the Thorny Crown to Fight Off COVID-19 |
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Liu YM, Mahmud Md. SA, Chen XR, Chen TH, Liao KS, Lo JM, Wu YM, Ho MC, Wu CY, Wong CH, Jan JT, Ma C
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Through the looking glass of cryoEM, unveiling the unique molecular structure and camouflaging sugar coating of feline coronavirus surface spike protein |
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Yang TJ, Chang YC, Ko TP, Draczkowski P, Chien YC, Chang YC, Wu KP, Khoo KH, Chang HW*, >Hsu STD*
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Sharp Tools Make Good Work: The Early Success of ASCEM |
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Chen CY, Chang YC, Lin BL, Lin KF, Huang CH, Hsieh DL, Ko TP, Tsai MD*
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| ● |
New Research Highlight on the Lon Protease |
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| 1. |
Chien-Chu Lin, Shih-Chieh Su, Ming-Yuan Su, Pi-Hui Liang, Chia-Cheng Feng, Shih-Hsiung Wu, Chung-I Chang |
2.
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Shih-Chieh Su, Chien-Chu Lin, Hui-Chung Tai, Mu-Yueh Chang, Meng-Ru Ho, C. Satheesan Babu, Jiahn-Haur Liao, Shih-Hsiung Wu, Yuan-Chih Chang, Carmay Lim, Chung-I Chang |
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| Latest Publication |
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Filamentous chemokine CCL5 structure and the functional aspects. |
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Yuan YT, Guo TC, Wu CY, Yeh YQ, Wu CT, Hsu SY, Weng ZW, Ho MR, Hsu STD, Chen YC, Chang CR, Wu KP*, Jeng US*, Sue SC*.
Scientific Reports (2025)
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Elucidating the Mechanism Underlying UBA7•UBE2L6 Disulfide Complex Formation. |
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Chen PT, Yeh JY, Weng JH, Wu KP*.
eLife (2025)
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Structural insights into human PNPase in health and disease. |
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Li YC, Wang CH, Patra M, Chen YP, Yang WZ, Yuan HS.
Nucleic Acids Research (2025)
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Molecular basis of host recognition of human coronavirus 229E. |
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Tsai, YX, Chien YC, Hsu MF, Khoo KY, Hsu ST.
Nature Communications (2025)
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Oligomerization of protein arginine methyltransferase 1 and its functional impact on substrate arginine methylation. |
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Dang T, EswarKumar N, Tripathi SK, Yan C, Wang CH, Cao M, Paul TK, Agboluaje EO, Xiong MP, Ivanov I, Ho MC*, Zheng YG*
Journal of Biological Chemistry (2024)
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Site-Specific Histidine Aza-Michael Addition in Proteins Enabled by a Ferritin-Based Metalloenzyme. |
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Tsou JC, Tsou CJ, Wang CH, Ko ALA, Wang YH, Liang HH, Sun JC, Huang KF, Ko TP, Lin SY, and Wang YS.
J. Am. Chem. Soc. (2024)
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The QS regulator AphBvp promotes expression of the AHPND PirAvp and PirBvp toxins and may enhance virulence under acidic conditions. |
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Lin SJ, Le PT, Chang YC, Liu CY, Chen YH, Wu CJ, Huang HJ, Hsu KC, Ko TP, Tien NY, Wang HC, Lo CF, Wang HC.
International Journal of Biological Macromolecules (2024)
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Reverse hierarchical DED assembly in the cFLIP-procaspase-8 and cFLIP-procaspase-8-FADD complexes. |
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Yang CY, Tseng YC, Tu YF, KuoBJ, Hsu LC, Lien CI, Lin YS, Wang YT, Lu YC, Su TW, Lo YC*, Lin SC*.
Nature Communications (2024)
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HURP binding to the vinca domain of β-tubulin accounts for cancer drug resistance. |
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Saju A, Chen PP, Weng TH, Tsai SY, Tanaka A, Tseng YT, Chang CC, Wang CH, Shimamoto Y, Hsia KC.
Nature Communications (2024)
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Cryo-EM structure of 1.51 Angstroms mouse heavy-chain apoferritin in 290 nm gold foil holes (HexAuFoil). |
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Wang CH, Wu KP, Chang YC
EMPIAR (2024) More
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Dual protection by Bcp1 and Rkm1 ensures incorporation of uL14 into pre-60S ribosomal subunits. |
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Yeh MC, Hsu NH, Chu HY, Yang CH, Hsu PH, Chou CC, Shie JT, Lee WM, Ho MC*, Lo KY*
Journal of Cell Biology (2024)
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Use of phase plate cryo-EM reveals conformation diversity of therapeutic IgG with 50 kDa Fab fragment resolved below 6 Å. |
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Lin HH, Wang CH, Huang SH, Lin SY, Kato T, Namba K, Hosogi N, Song C, Murata K, Yen CH, Hsu TL, Wong CH, Wu YM, Tu IP, Chang WH
Scientific Reports (2024)
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The positively charged cluster in the N-terminal disordered region may affect prion protein misfolding: Cryo-EM structure of hamster PrP(23-144) fibrils. |
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Lee CH, Saw JE, Chen EH, Wang CH, Uchihashi T, Chen RP*
Journal of Molecular Biology (2024)
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Functional and structural investigation of a broadly neutralizing SARS-CoV-2 antibody. |
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Chang, YH, Hsu MF, Chen WN, Wu MH, Kong WL, Lu MYJ, Huang CH, Chang FJ, Chang LY, Tsai HY, Tung CP, Yu JH, Kuo Y, Chou YC, Bai LY, Chang YC, Chen Ay, Chen CC, Chen YH, Liao CC, Chang CS, Liang JJ, Lin YL, Angata T, Hsu STD*, Lin KI*
JCI Insight (2024)
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Structural Basis and Synergism of ATP and Na+ Activation in Bacterial K+ Uptake System KtrAB. |
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Chiang WTien, Chang YK, Hui WH, Chang SW, Liao CY, Chang YC, Chen CJ, Wang WC, Lai CC, Wang CH, Luo SY, Huang YP, Chou SH, Horng TL, Hou MH, Muench SP, Chen RS, Tsai MD*, Hu NJ*
Nature Communications (2024)
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| ● |
Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis. |
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Yang CY, Lien CI, Tseng YC, Tu YF, Kulczyk AW, Lu YC, Wang YT, Su TW, Hsu LC, Lo YC, Lin SC
Nature Communications (2024)
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| ● |
Structural Insight into the ZFAND1-p97 Interaction Involved in Stress Granule Clearance. |
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Lai CH, Ko KT, Fan PJ, Yu TA, Chang CF, Draczkowski P, Hsu STD*
Journal of Biological Chemistry (2024)
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| ● |
Rapid simulation of glycoprotein structures by grafting and steric exclusion of glycan conformer libraries. |
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Tsai YX, Chang NE, Reuter K, Chang HT, Yang TJ, von Bülow S, Sehrawat V, Zerrouki M, Tuffery M, Gecht M, Grothaus IL, Ciacchi LC, Wang YS, Hsu MF, Khoo KH, Hummer G, Hsu STD*, Hanus C*, Sikora M*
Cell (2024)
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A unified view on enzyme catalysis by cryo-EM study of a DNA topoisomerase. |
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Chang CM, Wang SC, Wang CH, Pang AH, Yang CH, Chang YK, Wu WJ, Tsai MD*
Communications Chemistry (2024)
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| ● |
A structure of the relict phycobilisome from a thylakoid-free cyanobacterium. |
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Jiang HW, Wu HY, Wang CH, Yang CH, Ko JT, Ho HC, Tsai MD, Bryant DA, Li FW, Ho MC, Ho MY
Nature Communications (2023)
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A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. |
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Li S, Hsieh KY, Kuo CI, Lin TC, Lee SH, Chen YR, Wang CH, Ho MR, Ting SY, Zhang K, Chang CI
Nature Communications (2023)
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Development of AAV-delivered broadly neutralizing anti-human ACE2 antibodies against SARS-CoV-2 variants. |
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Sun CP, Chiu CW, Wu PY, Tsung SI, Lee IJ, Hu CW, Hsu MF, Kuo TJ, Lan YH, Chen LY, Ng HY, Chung MJ, Liao HN, Tseng SC, Lo CH, Chen YJ, Liao CC, Chang CS, Liang JJ, Draczkowski P, Puri S, Chang YC, Huang JS, Chen CC, Kau JH, Chen YH, Liu WC, Wu HC, Hsu STD, Wang IH, Tao MH
Molecular Therapy (2023)
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Structural basis of transcriptional activation by the OmpR/PhoB-family response regulator PmrA. |
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Lou YC*, Huang HY, Yeh HH, Chiang WH, Chen C*, Wu KP*
Nucleic Acids Research (2023)
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Structural basis for calcium-stimulating pore formation of Vibrio α-hemolysin. |
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Chiu YC, Yeh MC, Wang CH, Chen YA, Chang H, Lin HY, Ho MC, Lin SM
Nature Communications (2023)
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Structural convergence endows nuclear transport receptor Kap114p with a transcriptional repressor function toward TATA-binding protein. |
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Liao CC, Wang YS, Pi WC, Wang CH, Wu YM, Chen WY*, Hsia KC*
Nature Communications (2023)
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Visualizing the membrane disruption action of antimicrobial peptides by cryo-electron tomography. |
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Chen EH, Wang CH, Liao YT, Chan FY, Kanaoka Y, Uchihashi T, Kato K, Lai L, Chang YW, Ho MC*, Chen RP*
Nature Communications (2023)
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| ● |
A RAD51-ADP double filament structure unveils the mechanism of filament dynamics in homologous recombination. |
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Luo SC, Yeh MC, Lien YH, Yeh HY, Siao HL, Tu IP, Chi P, Ho MC*
Nat Commun. (2023)
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An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria. |
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Lu KJ, Chang CW, Wang CH, Chen FYH, Huang IY, Huang PH, Yang CH, Wu HY, Wu WJ, Hsu KC, Ho MC, Tsai MD*, Liao JC*
Nat Metab. (2023)
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| ● |
Cryo-EM reveals the structure and dynamics of a 723-residue malate synthase G. |
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Ho MR, Wu YM, Lu YC, Ko TP, Wu KP*
Journal of Structural Biology (2023)
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| ● |
Suppression of the human malic enzyme 2 modifies energy metabolism and inhibits cellular respiration. |
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Hsieh JY, Chen KC, Wang CH, Liu GY, Ye JA, Chou YT, Lin YC, Lyu CJ, Chang RY, Liu YL, Li YH, Lee MR, Ho MC*, Hung HC*
Communications Biology (2023)
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| ● |
Assessment of circulating extracellular vesicles from calorie-restricted mice and humans in ischaemic injury models. |
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Jaimes MSV, Liao CT, Chen MM, Czosseck A, Lee TL, Chou YH, Chen YM, Lin SL, Lai JJ, Lundy DJ*
Journal of Extracellular Biology (2023)
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| ● |
Lymph Node Follicle‐Targeting STING Agonist Nanoshells Enable Single‐Shot M2e Vaccination for Broad and Durable Influenza Protection. |
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Tsai HH, Huang PH, Lin LCW, Yao BY, Liao WT, Pai CH, Liu YH, Chen HW, Hu CMJ
Advanced Science (2023)
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| ● |
Multiple Nucleocapsid Structural Forms of Shrimp White Spot Syndrome Virus Suggests a Novel Viral Morphogenetic Pathway. |
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Huang HJ, Tang SL, Chang YC, Wang HC, Ng TH, Garmann RF, Chen YW, Huang JY, Kumar R, Chang SH, Wu SR, Chao CY, Matoba K, Kenji I, Gelbart WM, Ko TP, Wang AHJ, Lo CF, Chen LL*, Wang HC*
Int. J. Mol. Sci. (2023)
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Nano-On-Nano: Responsive Nanosubstrate-Mediated Liposome Delivery with High Cellular Uptake Efficiency. |
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Gautam B, Luo CH, Gao HD, Hsiao JC, Tseng HR*, Lee HM*, Yu HH*
ACS Appl. Bio Mater. (2023)
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| ● |
Structures of honeybee-infecting Lake Sinai virus reveal domain functions and capsid assembly with dynamic motions. |
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Chen NC, Wang CH, Yoshimura M, Yeh YQ, Guan HH, Chuankhayan P, Lin CC, Lin PJ, Huang YC, Wakatsuki S, Ho MC*, Chen CJ*
Nature Communications (2023)
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| ● |
Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2. |
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Huang KY*, Chen XR, Mohapatra A, Nguyen HTV, Schimanski L, Tan TK, Rijal P, Vester SK, Hills RA, Howarth M, Keeffe JR, Cohen AA, Kakutani LM, Wu YM, Mahmud Md SA, Chou YC, Bjorkman PJ, Townsend AR, Ma C*
Nature Communications (2023)
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| ● |
In situ structure and dynamics of an alphacoronavirus spike protein by cryo-ET and cryo-EM. |
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Huang CY, Draczkowski P, Wang YS, Chang CY, Chien YC, Cheng YH, Wu YM, Wang CH, Chang YC, Chang YC, Yang TJ, Tsai YX, Khoo KH, Chang HW, Hsu STD*
Nature Communications (2022)
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| ● |
2.2 Å Cryo-EM Tetra-Protofilament Structure of the Hamster Prion 108–144 Fibril Reveals an Ordered Water Channel in the Center. |
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Chen EHL, Kao HW, Lee CH, Huang JYC, Wu KP*, Chen RPY*
J. Am. Chem. Soc. (2022)
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Enzymology and Dynamics by Cryogenic Electron Microscopy. |
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Tsai, MD*, Wu WJ, Ho MC
Annual review of biophysics (2022)
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| ● |
Structural basis for the helical filament formation of Escherichia coli glutamine synthetase. |
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Huang PC, Chen SK, Chiang WH, Ho MR, Wu KP*
Protein Science (2022)
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| ● |
Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models. |
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Huang HY, Liao HY, Chen XR, Wang SW, Cheng CW, Mahmud MSA, Liu YM, Mohapatra A, Chen TH, Lo JM, Wu YM, Ma HH, Chang YH, Tsai HY, Chou YC, Hsueh YP, Tsai CY, Huang PY Chang SY, Chao TL, Kao HC, Tsai YM, Chen YH, Wu CY, Jan JT, Cheng TJR, Lin KI*, Ma C*, Wong CH*
Science Translational Medicine (2022)
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A 10-nm-sized multicompartment cuboctahedron and its 2D hierarchical arrays observed by cryo-EM. |
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He LP, Hsu HK, Li LJ, Lin LT, Tu TH, Ong TG, Liou GG*, Chan YT*
Chem (2022)
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| ● |
Distinct shifts in site-specific glycosylation pattern of SARS-CoV-2 spike proteins associated with arising mutations in the D614G and Alpha variants. |
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Kuo CW, Yang TJ, Chien YC, Yu PY, Hsu STD*, Khoo KH*
Glycobiology (2022)
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Liposomal PHD2 Inhibitors and the Enhanced Efficacy in Stabilizing HIF-1α. |
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Jian CB, Yu XE, Gao HD, Chen HA, Jheng RH, Chen CY, Lee HM*
Nanomaterials (Basel) (2022)
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Multifunctional carbonized nanogels to treat lethal acute hepatopancreatic necrosis disease. |
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Yen SC, Mao JY, Lin HY, Huang HT, Harroun SG, Nain A, Chang HT, Lin HY, Chen LL, Huang CC, Lin HJ
J Nanobiotechnol (2021)
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Catalytic machinery of methane oxidation in particulate methane monooxygenase (pMMO). |
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Chan S I, Chang WH, Huang SH, Lin HH, Yu S SF
J Inorg Biochem (2021)
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Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex. |
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Li SS, Hsieh KY, Kuo CI, Su SC, Huang KF, Zhang KM, Chang CI
Science Advances (2021)
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Structure-guided antibody cocktail for prevention and treatment of COVID-19. |
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Su SC, Yang TJ, Yu PY, Liang KH, Chen WY, Yang CW, Lin HT, Wang MJ, Lu RM, Tso HC, Chung MJ, Hsieh TY, Chang YL, Lin SC, Hsu FY, Ke FY, Wu YH, Hwang YC, Liu IJ, Liang JJ, Liao CC, Ko HY, Sun CP, Wu PY, Jan JT, Chang YC, Lin YL*, Tao MH*, Hsu STD*, Wu HC*
PLOS Pathogens (2021)
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Complete three-dimensional structures of the Lon protease translocating a protein substrate. |
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Li SS, Hsieh KY, Kuo CI, Lee SH, Pintilie GD, Zhang KM, Chang CI
Science Advances (2021)
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| ● |
Molecular basis for ATPase-powered substrate translocation by the Lon AAA+ protease. |
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Li SS, Hsieh KY, Su SC, Pintilie GD, Zhang KM, Chang CI
Journal of Biological Chemistry (2021)
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| ● |
D614G mutation in the SARS-CoV-2 spike protein enhances viral fitness by desensitizing it to temperature-dependent denaturation. |
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Yang TJ, Yu PY, Chang YC, Hsu STD*
Journal of Biological Chemistry (2021)
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| ● |
Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-Polyethylene Glycol Antibodies. |
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Chen BM, Cheng TL, Roffler SR
ACS Nano (2021)
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| ● |
Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function. |
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Yang TJ, Yu PY, Chang YC, Liang KH, Tso HC, Ho MR, Chen WY, Lin HT, Wu HC, Hsu STD*
Nature Structural & Molecular Biology (2021)
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| ● |
Copper Centers in the Cryo-EM Structure of Particulate Methane Monooxygenase Reveal the Catalytic Machinery of Methane Oxidation. |
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Chang WH*, Lin HH, Tsai IK, Huang SH, Chung SC, Tu IP, Yu SSF*, Chan SI*
J. Am. Chem. Soc. (2021)
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| ● |
Preparation of High-Temperature Sample Grids for Cryo-EM. Video |
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Chang YC, Chen CY, Tsai MD*
Jove - Journal of Visualized Experiments (2021)
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| ● |
Sub-3 Å Cryo-EM Structures of Necrosis Virus Particles via the Use of Multipurpose TEM with Electron Counting Camera |
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Wang CH, Chen DH, Huang SH, Wu YM, Chen YY, Hwu YK, Bushnell D, Kornberg R, Chang WH*
International Journal of Molecular Sciences (2021)
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Robust induction of resident memory T cells by combinatorial nanoshells confers cross-strain sterilizing immunity against lethal influenza viruses. |
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Lin PH, Liang CY, Yao BY, Chen HW, Pan CF, Wu LL, Lin YH, Hsu YS, Liu YH, Chen PJ, Hu CMJ, Yang HC
Methods & Clinical Development (2021)
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| ● |
Impact of Glycosylation on SARS-CoV-2 Infection and Broadly Protective Vaccine Design. |
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Liao HY, Huang HY, Chen XR, Cheng CW, Wang SW, Mahmud MSA, Chen TH, Lo JM, Liu YM, Ma HH,Chang YH, Tsai CY, Huang PY, Chang SY, Chao TL, Kao HC, Tsai YM, Chen YH, Chen CY, Lee KC, Wu CY, Jan JT, Kuo-I Lin, Cheng TJR, Ma C, Wong CH
bioRxiv (2021)
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| ● |
Direct Visualization of a 26 kDa Protein by Cryo-Electron Microscopy Aided by a Small Scaffold Protein. |
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Chiu YH, Ko KT, Yang TJ, Wu KP, Ho MR, Draczkowski P*, Hsu STD*
Biochemistry (2021)
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| ● |
Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures. |
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Luo SC, Yeh HY, Lan WH, Wu YM, Yang CH, Chang HY, Su GC, Lee CY, Wu WJ, Li HW, Ho MC*, Chi P*, Tsai MD*
Nat Commun (2021)
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Discrete Metal-Oxide Clusters with Organofunctionalization as High-Performance Anode Materials. |
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Jadhav TS, Abbas SA, Liu YC, Wu WT, Lee GH, Chu CW, Chiang MH
ACS Appl. Energy Mater. (2021)
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| ● |
A carbohydrate-binding protein from the edible Lablab beans effectively blocks the infections of influenza viruses and SARS-CoV-2. |
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Liu YM, Mahmud Md. SA, Chen XR, Chen TH, Liao KS, Lo JM, Wu YM, Ho MC, Wu CY, Wong CH, Jan JT, Ma C
Cell Reports (2020)
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| ● |
Premature Drug Release from Polyethylene Glycol (PEG)-Coated Liposomal Doxorubicin via Formation of the Membrane Attack Complex. |
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Chen V, Chen BM, S YC, Chang YC, Cheng TL, Barenholz, Roffler SR
ACS Nano (2020)
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| ● |
XFEL coherent diffraction imaging for weakly scattering particles using heterodyne interference. |
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Huang CF, Chang WH, Lee TK, Joti Y., Nishino Y., Kimura T., Suzuki A., Bessho Y., Lee TT, Chen MC, Yang SM, Hwu Y., Huang SH, Li PN, Chen P., Tseng YC, Ma C., Hsu TL., Wong CH, Tono K., Ishikawa T., Liang KS
AIP Advances (2020)
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Synthetic Immunogenic Cell Death Mediated by Intracellular Delivery of STING Agonist Nanoshells Enhances Anticancer Chemo-immunotherapy. |
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Chattopadhyay S, Liu YH, Fang ZS, Lin CL, Lin JC, Yao BY, Hu CMJ
Nano Lett. (2020)
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Cholesteryl α-D-glucoside 6-acyltransferase enhances the adhesion of Helicobacter pylori to gastric epithelium. |
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Jan HM, Chen YC, Yang TC, Ong LL, Chang CC, Muthusamy S, Abera AB, Wu MS, Gervay-Hague J, Mong KKT, Lin CH
Communications Biology (2020)
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Cryo-EM analysis of a feline coronavirus spike protein reveals a unique structure and camouflaging glycans. |
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Yang TJ, Chang YC, Ko TP, Draczkowski P, Chien YC, Chang YC, Wu KP, Khoo KH, Chang HW, Hsu STD
PNAS (2020)
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Temperature-Resolved Cryo-EM Uncovers Structural Bases of Temperature-Dependent Enzyme Functions. |
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Chen CY, Chang YC, Lin BL, Huang CH, Tsai MD
J Am Chem Soc. (2019)
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pH-Responsive PEG-Shedding and Targeting Peptide-Modified Nanoparticles for Dual-Delivery of Irinotecan and microRNA to Enhance Tumor-Specific Therapy. |
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Juang V, Chang CH, Wang, CS, Wang HE, Lo YL
Small (2019)
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Viromimetic STING Agonist‐Loaded Hollow Polymeric Nanoparticles for Safe and Effective Vaccination against Middle East Respiratory Syndrome Coronavirus. |
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Lin, LCW, Huang CY, Yao BY, Lin JC, Agrawal A, Algaissi A, Peng BH, Liu YH, Huang PH, Juang RH, Chang YC, Tseng CT*, Chen HW*, Hu CMJ*
Advanced Functional Materials (2019)
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Use of Cryo-EM to Uncover Structural Bases of pH Effect and Cofactor Bi-specificity of Ketol-acid Reductoisomerase. |
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Chen CY, Chang YC, Lin BL, Lin KF, Huang CH, Hsieh DL, Ko TP, Tsai MD
J Am Chem Soc. (2019)
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Egg-based influenza split virus vaccine with monoglycosylation induces cross-strain protection against influenza virus infections. |
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Tseng YC, Wu CY, Liu ML, Chen TH, Chiang WL, Yu YH, Jan JT, Lin KI, Wong CH, Ma C
PNAS (2019)
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3D mitochondrial ultrastructure of Drosophila indirect flight muscle revealed by serial-section electron tomography. |
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Jiang YF, Lin HL, Fu CY
J Vis Exp. (2017)
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Electron tomographic analysis reveals ultrastructural features of mitochondrial cristae architecture which reflect energetic state and aging. |
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Jiang YF, Lin SS, Chen JM, Tsai HZ, Hsieh TS, Fu CY
Sci Rep. (2017)
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Structural Basis for the Magnesium-Dependent Activation and Hexamerization of the Lon AAA+ Protease. |
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Su SC, Lin CC, Tai HC, Chang MY, Ho MR, Babu CS, Liao JH, Wu SH, Chang YC, Lim C, Chang CI
Structure (2016)
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EM structure of a helicase-loader complex depicting a 6:2 binding sub-stoichiometry from Geobacillus kaustophilus HTA426. |
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Lin YC, Naveen V, Hsiao CD.
Biochem Biophys Res Commun (2016)
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Structure of yeast Ape1 and its role in autophagic vesicle formation. |
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Su MY, Peng WH, Ho MR, Su SC, Chang YC, Chen GC, Chang CI
Autophagy (2015)
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