Visualization of the first contact between the earliest reported human coronavirus and its human receptor molecule Tsai, YX, Chien YC, Hsu MF, Khoo KY, Hsu ST Coronavirus 229E is the earliest reported human coronavirus (hCoV-229E). Here, the authors used cryo-EM, glycoproteomics, and modeling to generate... Read more

Cryo-EM and cryo-ET reveal the molecular architecture and host interactions of mycobacteriophage Douge.

Maharana J, Wang CH, Tsai LA, Liao YT, Yang CH, Shen MC, Macale LS, Tran TN, Narsico J, Perez RJ, Tewary SK, Wu JL, Lin HY, Chang SW, Franklin A, Moynihan PJ, Jacobs-Sera D, Freeman KG, Hatfull GF, Lowary TL, Ho MC. Cell Reports (2025)

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Human glycogenins maintain glucose homeostasis by regulating glycogen metabolism.

Weng TH, Pien YC, Chen CJ, Chen PP, Tseng YT, Chen YC, Hsiao WP, Lee YT, Chen YA, Chen YC, Lim C, Hsu TH, LIn SJ, Yen HY, Hsia KC, Tsai SY. Nature Communications (2025)

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Real-space heterogeneous reconstruction, refinement, and disentanglement of CryoEM conformational states with HetSIREN.

Herreros D, Mata CP, Noddings C, Irene D, Krieger J, Agard DA, Tsai MD, Sorzano COS, Carazo JM. Nature Communications (2025)

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