Production of active legume lectins, and altering their ability to bind to different glycans. Liu YM, Nguyen HTV, Chen X, Mahmud SA Md, ChenTH, Liao KS, Lo JM, Kan TC, Ren CT, Ma C.  FRIL is a hyacinth bean lectin that has broad-spectrum antiviral activity by binding to complex type N-glycans on viruses. Recently, Dr. Che Ma’s group at Academia Sinica Genomics Research Center has demonstrated that FRIL’s recognition of complex type N-glycans and... Read more

BMAL1–HIF2A heterodimer modulates circadian variations of myocardial injury. Ruan W*, Li T, Bang IH, Lee J, Deng W,...Tsai KL*, Eltzschig HK*.  Acute myocardial infarction is a leading cause of morbidity and mortality worldwide. Clinical studies have shown that the severity of cardiac injury after myocardial infarction exhibits a circadian pattern, with larger infarcts and poorer outcomes in patients experiencing morning-onset events. However, the molecular mechanisms underlying these diurnal variations remain unclear.... Read more

Pentameric Architecture of the SARS-CoV-2 Envelope Protein Revealed by SEC-MALS, Cryo-EM, and Molecular Dynamics.

Weng ZW, Farhat D, Lee JY, Hsu STD. The Journal of Physical Chemistry B (2026)

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Altering the carbohydrate-binding specificity of the legume lectin FRIL through structure-guided engineering.

Liu YM, Nguyen HTV, Chen X, Mahmud SA Md, ChenTH, Liao KS, Lo JM, Kan TC, Ren CT, Ma C. Nature Communications (2026)

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Mechanistic Insights into Unary Peptide–Membrane Interactions Enable Stable Encapsulation and Trigger-Responsive Peptidyl Liposomes.

Gao HD, Hong JL, Jian CB, Chen TH, Chang NC, Meeroekyai S, He RY, Liao YT, Wang CH, Su CJ, Jeng US, Ho MC, Chen YJ, Lee HM. Journal of the American Chemical Society (2026)

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