Academia Sinica-Cryo-EM Structure of the Vaccinia Virus Entry Fusion Complex Reveals a Multicomponent Fusion Machinery. Lin CSH, Li CA, Wang CH, Kao CF, Chiu HJ, Yeh MC, Gao HD, Ho MC, Lee HM, Chang W.  Membrane fusion is essential for viral entry. Unlike class I–III fusion proteins, vaccinia virus employs a multi-component Entry Fusion Complex (EFC). Using cryo–electron microscopy, we determined the full-length structure of the vaccinia EFC... Read more

Pentameric Architecture of the SARS-CoV-2 Envelope Protein Revealed by SEC-MALS, Cryo-EM, and Molecular Dynamics.

Weng ZW, Farhat D, Lee JY, Hsu STD. The Journal of Physical Chemistry B (2026)

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Mechanistic Insights into Unary Peptide–Membrane Interactions Enable Stable Encapsulation and Trigger-Responsive Peptidyl Liposomes.

Gao HD, Hong JL, Jian CB, Chen TH, Chang NC, Meeroekyai S, He RY, Liao YT, Wang CH, Su CJ, Jeng US, Ho MC, Chen YJ, Lee HM. Journal of the American Chemical Society (2026)

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Multiscale Simulations and Cryo-Electron Microscopy Reveal the Transition Pathway of Dengue Virus-like Particle Nanoassembly.

Palur VR, Chen GW, Chao DY, Kuo WS, Wu YN, Galula JU, Wang CH, Chen FC, Bond PJ, Marzinek JK, Wu SR. ACS Nano (2026)

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